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KMID : 0358420120550020069
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Korean Journal of Obstetrics and Gynecology
2012 Volume.55 No. 2 p.69 ~ p.75
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Clinical significance of preoperative serum CA-125 level in epithelial ovarian cancer
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Lee Seung-Ho
Yoo Hye-Seung
Shin Jin-Woo
Park Chan-Yong
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Abstract
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Objective: This study was performed to evaluate the clinical significance of preoperative CA-125 level in epithelial ovarian cancer.
Methods: Seventy nine patients with epithelial ovarian cancer who were operated at Gachon University Gil Hospital from January 2002 to December 2009 were included. Medical records including pathologic reports were reviewed retrospectively. Overall survival was analyzed by Kaplan-Meier method and log-rank test was used for curve comparison. Cox proportional hazards model was used for multivariate analysis.
Results: Mean age was 52.3 years old and mean body mass index was 24.0. Histologically, malignant serous tumor was the most common histologic type (60.1%) and 46 patients had grade III tumor (58.2%). FIGO stage III was most common (58.2%) and 46 patients (58.2%) had residual disease less than 1 cm. In univariate analysis, age (P = 0.01), stage (P = 0.00), residual disease (P = 0.01) and preoperative CA-125 level (P = 0.03) were significant prognostic factors affecting survival. Patients less than 50 years old showed longer overall survival rate than patients over 50 years old. Stage I/II patients showed longer overall survival rate than stage III/IV patients. Patients with residual disease less than 1 cm showed longer overall survival rate than patients with residual disease over 1 cm. Patients with CA-125 level under 500 U/mL had significantly longer survival rate than patients with CA-125 level over 500 U/mL. However, multivariate analysis revealed none of these factors were significant independent prognostic factors.
Conslusion: To evaluate the clinical significance of preoperative CA-125 level in epithelial ovarian cancer, prospective study is needed.
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KEYWORD
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Ovarian neoplasms, CA-125, Survival
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